FREE delivery on orders over £100
0 item(s)£0.00
Call FREE 0800 772 3771
As recommended by www.bluebadgestyle.com

Blog


Guest Article by Arthritis Digest - Brain Chemical Gives New Clues In Treating Chronic Pain

By Guest Blog Post  |  19 Dec 2017 17:00:00

brain neuron  Birth Into Being
Image credit: Birth Into Being
 

A chemical in the brain usually associated with movement, reward-motivation behaviour and cognition may also play a role in promoting chronic pain, according to experts from The University of Texas in Dallas.

A research group followed the sequence of pain impulses travelling from the brain to the spinal cord in mice. They found that by removing a collection of neurons (called A11) that contain dopamine, chronic pain was diminished.

"These findings demonstrate a novel role for how dopamine contributes to maintaining chronic pain states," explains Dr Ted Price who is involved in the research. "This may open up new opportunities to target medicines that could reverse chronic pain."

We know that pain signals travel like electricity from an injury to the spinal cord where they pass pain signals to other cells. Those pain signals then travel upward and relay the information to neurons in the brain. There is no one pain centre in the brain, but experts believe that chronic pain may change how these pain centres are activated.

In people with chronic pain, neurons continue to send pain signals to the brain, even in the absence of injury. We don’t yet know why but it could be because of the A11 neurons. The current research found that these neurons didn't affect acute pain, but they did have a profound effect on chronic pain. By targeting these neurons in mice with chronic pain, the researchers permanently reversed a chronic pain state.

"In future studies, we would like to gain a better understanding of how stress interacts with A11," Dr Price says. "And we'd like to know more about the interaction between molecular mechanisms that promote chronic pain and dopamine."

Source: Arthritis Digest magazine, http://arthritisdigest.co.uk

 

 

Blog Search

About the Authors

Katherine
katherine
Guest Blog Post
Share on Facebook Share on Twitter Share on Google+ Share on Linked In Share on Pinterest Email to a friend More options
Close
Share on Facebook Share on Twitter Share on Google+ Share on Linked In Share on Pinterest Email to a friend More options
Share
Share on Facebook

Facebook

Share on Twitter

Twitter

Share on Google+

Google+

Share on Pinterest

Pinterest

Email to a friend

Email

Share on Linked In

Linked In

Share on Instagram

Instagram

Share on Tumblr

Tumblr

Share on Wordpress

Wordpress

Share on your blog

Re-blog

Close
Online - Start Chat?

Your name *

 

Cancel